Parasit Plasmodium malaria memerlukan lipid dari tuan rumah (badan manusia). Tetapi bagaimana parasit malaria begitu berjaya dalam mewujudkan diri mereka dalam badan manusia? Apa sumber lipid tidak parasit berkembang maju ? Penyelidik (Olarewaju Oluba, Augustine Olusola, et al) di Joseph Ayo Babalola University, Nigeria, yang membangunkan kajian haiwan untuk memantau kepekatan serum lipid dan hati semasa peringkat jangkitan malaria.
Cendawan Reishi ubatan telah digunakan dalam ubat-ubatan tradisional selama lebih seribu tahun. Para penyelidik Nigeria mahu menyiasat dan melihat jika cendawan perubatan Reishi boleh menghalang pembiakan parasit malaria pada tikus.
Cendawan Reishi perubatan telah disusun, dicuci, kering, dan kemudian dihancurkan kepada serbuk. 100 gram tepung Reishi ini direndam di dalam 1000 ml air suling, dimasukkan ke dalam shaker orbit selama 48 jam, kemudian ditapis dan sejat.
Cendawan perubatan Reishi mempunyai ciri-ciri anti malaria Tikus telah dijangkiti parasit malaria dan diberi pelbagai dos ekstrak cendawan ubatan yang Reishi. Terdapat kumpulan kawalan juga. Hati mereka, buah pinggang dan tahap kolesterol diuji.
Tikus dijangkiti parasit malaria telah meningkat paras kolesterol. Tetapi terdapat penurunan ketara dalam serum kolesterol dalam tikus yang dirawat dengan ubat cendawan Reishi. Dan dengan kumpulan kawalan yang diberikan tidak Reishi, kiraan parasit meningkat sehingga tikus itu mati.
Dalam eksperimen haiwan ini, ekstrak cendawan Reishi ubatan mengurangkan jumlah parasit malaria dalam hati lipoprotein kolesterol. Bolehkah cendawan ubatan ini menjadi sebahagian daripada penawar baru bagi malaria? kajian haiwan ini telah menimbulkan harapan bagi ubat baru untuk malaria, dari ekstrak Reishi cendawan perubatan. Mampukah Reishi menamatkan penyakit pembunuh ini?
English
Malaria kills over a million people every year, many of them children. In 2010, the World Health Organization estimated there were 219 million cases of malaria. This mosquito-borne infectious disease has developed a resistance to some antimalarial drugs, so finding new cures are an urgent research topic.
In order to reproduce inside the host body, the malarial parasite Plasmodium needs lipids from the host. But how are the malaria parasites so successful in establishing themselves in human hosts? What source of lipids does the parasite thrive on? Researchers (Olarewaju Oluba, Augustine Olusola, et al) at the Joseph Ayo Babalola University, Nigeria, developed an animal study to monitor serum and liver lipid concentrations during the infection stage of malaria.
Reishi medicinal mushroom has been used in traditional medicines for over a thousand years. The Nigerian researchers wanted to investigate reishi’s cholesterol lowering properties, to see if reishi medicinal mushroom could prevent the proliferation of malarial parasites in mice.
Fruiting bodies of reishi medicinal mushroom were sorted, washed, dried, and then ground to a powder. 100 grams of this powdered reishi was soaked in 1000 ml distilled water, put in an orbital shaker for 48 hours, then filtered and evaporated.
Mice were infected with the malaria parasites and given various doses of the reishi medicinal mushroom extract. There was a control group, too. Their liver, kidneys and cholesterol levels were tested.
The mice infected with malaria parasites had increased cholesterol levels. But there was a significant decrease in serum cholesterol in the mice treated with reishi medicinal mushroom. And with the control group given no reishi, the parasite count increased until the mice died.
In this animal experiment, the Reishi medicinal mushroom extract reduced the amount of malarial parasites in liver lipoprotein cholesterol. Could this medicinal mushroom become part of a new cure for malaria?
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